Clinical Dossier · Edition 01

The science of seamless travel.

Travel disrupts the gut in measurable, predictable ways — microbial diversity declines, motility shifts, the intestinal barrier loosens. Each vivagut formula targets a specific stage of that disruption with ingredients selected from human randomized controlled trials. Below: every active, every dose, every paper.

Stage-specific formulation

Three formulas, three windows. Prepare primes the microbiome 5–7 days pre-travel. Shield protects the barrier during transit. Recover resolves residual inflammation post-trip.

ii.

Clinically studied actives

Every ingredient is supported by at least one peer-reviewed human RCT. Doses are aligned to the doses tested in those trials wherever traveler-relevant data exists.

iii.

Standardized extracts

Where applicable, botanicals are standardized to their characterized active compounds — 95% curcuminoids, 95% quercetin, 5% gingerols — to match what the studies tested.

Stage 01 · Pre-travel

Prepare.

Primes your gut before adventure.

Take 2 capsules daily, 5–7 days before travel
Servings per bottle 7
Format 14 vegan capsules

01 / 05

Saccharomyces boulardiiProbiotic yeast · CFU-standardized

10 BILLION CFU · 500 MG

MechanismA non-colonizing probiotic yeast that occupies binding sites on the intestinal wall, neutralizes bacterial toxins (E. coli, C. difficile), and reinforces the mucosal barrier — without being killed by stomach acid or affected by antibiotics.

02 / 05

Bacillus coagulansSpore-forming probiotic · shelf-stable

2 BILLION CFU · 40 MG

MechanismSpore-forming probiotic that survives heat, gastric acid, and bile — germinating only in the small intestine, where it produces lactic acid, normalizes stool form, and reduces post-prandial bloating. Uniquely suited to luggage and cabin storage.

03 / 05

InulinCichorium intybus root · prebiotic fiber

200 MG

MechanismA fermentable fiber that selectively feeds resident Bifidobacterium, increases short-chain fatty acid production, and strengthens the mucosal barrier before exposure to foreign microbes — the synbiotic complement to the probiotic strains.

04 / 05

GingerZingiber officinale root · 5% gingerols

50 MG · 2.5 MG GINGEROLS

MechanismGingerols and shogaols accelerate gastric emptying, stimulate antral contractions, and antagonize 5-HT₃ serotonin receptors — the same receptors targeted by motion-sickness drugs. Pre-travel dosing primes the gastric rhythm before flights.

05 / 05

Magnesium glycinateChelated form · gentle on the gut

50 MG · 12% DV

MechanismThe diglycinate (chelated) form is absorbed in part as an intact dipeptide via small-intestine peptide transporters — delivering magnesium without the osmotic, laxative effect of magnesium oxide or citrate. Critical pre-travel: oxide can itself trigger loose stools.

Stage 02 · During travel

Shield.

Supports digestive comfort during travel.

Take 2 capsules daily, throughout the trip
Servings per bottle 7
Format 14 vegan capsules

01 / 05

Zinc L-carnosinePolaprezinc · chelated zinc + L-carnosine complex

30 MG · 273% DV

MechanismAdheres to the mucosal lining and locally releases zinc to support tight-junction proteins (occludin, ZO-1) — directly addressing the elevated intestinal permeability caused by heat, exercise, NSAIDs, alcohol, and unfamiliar pathogens. Polaprezinc concentrates at the gut wall instead of dispersing systemically like other zinc forms.

02 / 05

Deglycyrrhizinated licoriceGlycyrrhiza glabra · DGL

400 MG

MechanismDGL stimulates mucus secretion in the gastric and esophageal lining, providing a protective coating against acid, alcohol, and irritants — without the blood-pressure side effects of whole licorice (glycyrrhizin removed). Reinforces the gut’s native defenses without altering gastric pH.

03 / 05

GingerZingiber officinale root · 5% gingerols

150 MG · 7.5 MG GINGEROLS

MechanismAt the higher Shield dose (3× Prepare), ginger’s 5-HT₃ receptor antagonism is most relevant — the same mechanism behind ondansetron — applied to the motion-induced nausea, slow gastric emptying after airline meals, and bloating that follow long sedentary periods.

04 / 05

ChamomileMatricaria chamomilla flower · 10:1 extract

50 MG · 500 MG EQUIVALENT

MechanismApigenin and bisabolol act as smooth-muscle relaxants in the intestinal wall via K⁺-channel activation and Ca²⁺-channel modulation. Apigenin also binds the GABA-A benzodiazepine site — addressing the anxious-stomach component of new-place GI distress, without dependency.

05 / 05

Aloe veraAloe barbadensis leaf · 200:1 extract

50 MG · 10,000 MG EQUIVALENT

MechanismAcemannan and polysaccharides in aloe form a soothing film over irritated mucosa and modulate inflammatory cytokines (TNF-α, IL-6) in the gut wall — particularly useful in diarrhea-predominant disruptions and the abdominal pain that often spikes during travel.

Stage 03 · Post-travel

Recover.

Supports recovery after travel stress.

Take 2 capsules daily, 5–7 days after travel
Servings per bottle 7
Format 14 vegan capsules

01 / 06

TurmericCurcuma longa root · 95% curcuminoids

500 MG · 475 MG CURCUMINOIDS

MechanismCurcumin downregulates NF-κB signaling, reducing post-travel inflammatory mediators (CRP, TNF-α, IL-6) that linger after exposure to foreign microbes, sleep disruption, and cabin hypoxia. Bioavailability is poor on its own — paired with BioPerine for absorption.

02 / 06

QuercetinSophora japonica · 95% quercetin dihydrate

150 MG · 142.5 MG QUERCETIN

MechanismA flavonoid that stabilizes mast cells, inhibits NF-κB, and acts as a potent antioxidant — addressing the histamine reactivity, oxidative load, and sleep-debt inflammation that accompany return travel. Also accelerates muscle-recovery markers in exercising adults.

03 / 06

BioPerine®Piper nigrum fruit · 95% piperine

10 MG

MechanismPiperine inhibits hepatic and intestinal glucuronidation and P-glycoprotein efflux, slowing the metabolism of co-administered compounds — keeping curcumin and quercetin in circulation long enough to act. Without it, oral curcumin’s serum levels are vanishingly low.

04 / 06

GingerZingiber officinale root · 5% gingerols

50 MG · 2.5 MG GINGEROLS

MechanismIn Recover, ginger plays its second role: anti-inflammatory rather than anti-nausea. Gingerols inhibit COX-1, COX-2, and 5-LOX pathways and lower IL-6 and TNF-α — supporting the resolution phase as the GI tract returns to baseline.

05 / 06

ChamomileMatricaria chamomilla · 10:1 extract

50 MG · 500 MG EQUIVALENT

MechanismIn Recover, chamomile’s purpose shifts from in-flight anxiety to re-entrainment of sleep. Apigenin’s GABA-A activity supports sleep onset and quality — critical for resetting circadian rhythm after time-zone change, the phase when the immune system performs most of its overnight repair.

06 / 06

Magnesium glycinateChelated form · gentle on the gut

50 MG · 12% DV

MechanismIn Recover, magnesium’s role is HPA-axis downregulation and sleep support rather than digestive priming. The glycinate form delivers both magnesium (cofactor for melatonin synthesis and parasympathetic tone) and glycine (an inhibitory neurotransmitter shown to improve subjective sleep quality on its own).

Our standard

How we built these formulas.

Clinically aligned doses

Each active is dosed inside the range used in published human clinical trials. Where evidence supports a higher dose for a more pronounced effect (e.g. S. boulardii at 1 g/day), we’ve sized the daily serving to match.

ii.

No proprietary blends

Every milligram is on the label. Proprietary blends obscure individual ingredient amounts and make the dossier impossible to read. We don’t use them.

iii.

Standardized extracts

Where the active fraction matters — gingerols in ginger, curcuminoids in turmeric, quercetin in Sophora japonica, glycyrrhizin removed in licorice — we specify the standardization on the label, the way the trials report it.

iv.

Form selection over substance

Magnesium as glycinate (not oxide). Zinc as L-carnosine (not picolinate). Licorice as DGL (no glycyrrhizin). Curcumin paired with piperine. The form is the dose.

Manufacturing

Manufactured in the USA in a cGMP-certified facility. Vegan capsules. Free from gluten, sugar, GMO, milk, eggs, fish, shellfish, tree nuts, peanuts, wheat, soy, and sesame.

vi.

What this dossier is — and isn’t

We cite published evidence for each active at the dose used. We do not claim that the finished vivagut formula has been tested in a double-blind trial of its own. As we grow, this is the next milestone.

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